Ciência e terapia do câncer

New Strategies for Improving the Quality of Life of Cancer Survivors: Reversible p53 Inhibition

Abstract

Nesrine Benkafadar, Carolanne Coyat, Ruth Lloyd1, Jean-Luc Puel, Jing Wang

In recent years, with the improvement of cancer survival through more effective treatment, the emphasis has been in trying to minimize the side-effects caused by chemo- and radiotherapy, to ensure that patients have the best quality of life throughout their cancer journey. The tumor suppressor p53 is widely implicated in a broad range of cancers, and here we summarize its role and the possibilities of its manipulation to improve side effects during active treatment through survivorship.