Joao Requicha
Regenerative Medicine therapies aim to restore normal morphology and function of damaged tissues. Regenerative approaches are based on the use of stem cells, growth and differentiation factors, such as platelet-rich plasma, and biomaterials from natural or synthetic origin which can act as matrix or vehicle.
Mesenchymal stem cells could be obtained from adipose tissue, bone marrow, umbilical cord or dental tissues, among others. They can be differentiated into osteoblasts or chondroblasts, important for the treatment of musculoskeletal lesions, such as osteoarthritis, tendinitis or non-union fractures. Their regenerative, immunomodulatory, anti-inflammatory and antifibrotic effects are controlled by bioactive substances with autocrine and paracrine factors which constitute the cell secretoma. Cell-based immunotherapies are reported in different conditions such as inflammatory bowel disease, feline chronic gingivostomatitis, keratoconjunctivitis sicca, feline asthma or renal disease, as well as in neurological diseases like sequelae of distemper encephalitis or canine degenerative myelopathy. The synergy between medical and basic sciences and the demand for new therapeutic solutions will pave the way for the development of new Regenerative Medicine strategies.
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