Jornal de Histologia Molecular e Fisiologia Médica

Localization of Fructose 1, 6-Biphosphate in Nucleus of Smooth Muscle Cell

Abstract

Vikrant Singh

In the presence of divalent metal ions (Mg2+, Mn2+, Co2+, and Zn2+), fructose 1,6-bisphosphatase catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Gomori was the first to discover the enzyme (1943). Approximately 2000 articles on the kinetics and tissue distribution of FBPase were published during the next 60 years. Only a few of these studies, however, deal with the enzyme's subcellular distribution. FBPase was discovered in the perinuclear area of hepatic and renal cells by Saez et al. in 1996, and nuclear localization of FBPase in these cells was discovered by Yanez et al. in 2003.