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Investigation of the Allelic Frequency of 7 Autosomal loci in the Kurdish Population of Iran

Abstract

Gholamreza Homayounpour, Farouq Karimpour and Fatemeh Keshavarzi*

Introduction: The number of repeats of a single microsatellite may be different in different individuals, and this is the basis of their use in genetic fingerprinting. The aim of this study was to investigate of the allelic frequency of 7 autosomal loci in the Kurdish population of Iran.

Materials and Methods: Two fifty hundred men and women non-relatives of living Kurds in Kurdish provinces of Iran were randomly selected for the study of 7 autosomal markers (D16S539, D2S1338, D7S820, D21S11, D18S51, CFSIPO, and D13S317). After molecular analysis, allele’s frequency distributions and other population genetic parameters were done.

Results: The D21S11 and CFSIPO markers had the highest (0.8324) and the lowest (0.7400) polymorphism in the studied population, respectively. All of the 7 autosomal loci studied in Iranian Kurdish population had above 0.7 and 0.6 polymorphism and heterozygosity, respectively.

Conclusion: The degree of differentiation power or PD for 7 autosomal markers was between 0.730 and 0.884, which indicates a high differentiation power for all 7 markers.