Medicina Nuclear e Radioterapia

IMRT for Nasal Tumors – Local Control and Cosmetic Outcome

Abstract

Stefan Janssen, Christoph Glanzmann, David Holzmann and Gabriela Studer

Background: To evaluate local control and cosmetic outcome in patients with cancer in the nasal cavity/vestibule treated with intensity-modulated radiotherapy (IMRT).

Methods: From 06/2008 – 11/2012 15 consecutive patients presenting nasal cavity (n=5), ala of the nose (n=5) or nasal vestibule tumors (n=5) were treated in our institution either postoperatively (n=8) or as definitive treatment (n=7).

Results: Mean/median follow-up (FU) was 30/22 months (range 17-62). Two patients suffered from a local relapse. As a salvage therapy an ablatio nasi was carried out in curative intention in both patients. Thereafter no failure was reported. Local control rate, ultimate local control and overall survival after 2 years were 87%, 100% and 100%, respectively. None of the patients developed grade II or higher late sequels. Cosmetic outcome after RT was very satisfying so far.

Conclusion: IMRT for nasal tumors is effective and well tolerated. Radical surgical procedures can be saved for curative salvage treatment.