Toxicologia Ambiental e Analítica

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Abstract

Moustafa A Abbassy, Mamdouh A Marzouk, Sameeh A Mansour, Hassan A Shaldam and Abdel-Tawab H Mossa

The present study was designed to investigate the effect of lambda-cyhalothrin (LCH) on lipid peroxidation, oxidative stress biomarkers and the activity of Cytochrome P450 in male rats and the protective role of zinc. LCH was administrated orally to rats at dose 2.6 mg/kg b.wt. (Which represents 1/10 LD50) with 3 doses per week for 6 weeks (dose period). Rats were divided into four groups, eight rats for, each: (I) control group, (II) zinc group (Zn dose 227 mg/l in drinking water), (III) LCH-treated groups and LCH-Zn group (IV) as in group II and III. The present results demonstrated that LCH induced significant alteration in the activity of antioxidant enzymes (superoxide dismutase, SOD; catalase, CAT; glutathione-s-transferase, GST; glutathione peroxidase, GPx), glutathione reduced (GSH) and lipid peroxidation (LPO) levels and decreased cytochrome P450 (P450) activity in plasma of male rats. In contrast, zinc-LCH treatment showed insignificant difference, compared to control results, regarding LPO, GST, CAT and P450. LCH induced oxidative stress, lipid peroxidation and reduced P450 activity in the plasma of male rats. The overall results reveal the pronounced ameliorating effect of zinc in LCH-intoxicated rats.