Jornal de AIDS e Pesquisa Clínica

Iatrogenic Cushing's Syndrome Due to Pharmacokinetic Interaction of Intra-Ocular Corticosteroids and Lopinavir/Ritonavir in an HIV-Infected Adolescent: A Case Report

Abstract

Diana F Clarke, Carole Moloney and Ellen R Cooper

We report a perinatally HIV infected adolescent on a protease-inhibitor containing antiretroviral regimen who developed iatrogenic Cushing's syndrome while receiving intensive ophthalmic corticosteroid therapy for granulomatous panuveitis. Although pharmacokinetic drug interactions between protease inhibitors and oral/inhaled corticosteroids have previously been described, this is the first report involving ophthalmic administration of corticosteroids and lopinavir/ritonavir in an adolescent.