Jornal de Genômica Clínica e Médica

Genomic Insights into Antibiotic Resistance: Mechanisms and Countermeasures

Abstract

Lucy Maisie

Antibiotic resistance poses a significant threat to global health, necessitating a deeper understanding of its genomic underpinnings. This review explores various mechanisms by which bacteria acquire resistance genes, including mutations, horizontal gene transfer and mobile genetic elements. Furthermore, it discusses genomic approaches such as whole genome sequencing and metagenomics that elucidate the spread and evolution of resistance. Countermeasures against antibiotic resistance, such as novel drug development and precision medicine strategies informed by genomics, are also highlighted. Integrating genomic insights into clinical practice promises to enhance surveillance, diagnosis and treatment of resistant infections, thereby safeguarding public health.