Medicina Nuclear e Radioterapia

Evaluating the Efficacy of Bone Tracer ^99mTC-MDP in Detecting Individual Renal Function Compared to Renal Cortical Imaging Agent ^99mTC-DMSA

Abstract

Magda S. Hanafy, Maged Abdelgalil Hamed and Heba M. Elshafai

This study was performed to evaluate the usefulness of bone tracer 99mTC-MDP in detecting renal disorders by imaging of renal cortex for patients with cortical defect and estimation of split renal function (SRF) as compared with renal cortical imaging agent 99mTC-DMSA. In this study 23 patients (6 males, 17 females) with range age of 16y -75y (mean 45.6y ± 17.4y), and a total of 46 studies (using both 99mTC-DMSA and 99mTC-MDP per patient for left and right kidneys) were performed for detecting renal disorders. Both studies were performed within 48 hours between each other. SRF was calculated in all cases from renal uptake of the tracers into the region of interest by using computer acquired data of gamma camera. For detecting renal cortex abnormalities, all cortical scars and defects scars seen on 99mTc-DMSA scan were also detected by 99mTc-MDP.

The results showed that the non visualized kidney on 99mTC-DMSA scan was also non visualized on 99mTC-MDP. Also, there was a high correlation between SRF values obtained from 99mTC-MDP and 99mTC-DMSA, where (p>0.01, r= 0.93 for left kidney and r=0.0.92 for right kidney).

The similar SRF values of 99mTC-MDP and 99mTC-DMSA allow to use of 99mTC-MDP tracers for detecting both of bone and renal abnormalities.