Revisão do Jornal Árabe de Negócios e Gestão

Effects of TFM and Niclosamide on the Transcriptome and Putative Detoxification Pathways in a Lampricide−Tolerant Teleost

Abstract

Lawre Serti

It appears that lampreys have a different detoxification capacity than bony fishes, particularly teleosts, which accounts for TFM's superiority against lampreys. Notwithstanding, the general systems of resilience to the TFM and niclosamide blend and the components of niclosamide poisonousness all alone are inadequately perceived, particularly among non-target fishes. Here, we identified specific mRNA transcripts and functional processes that responded to niclosamide or a TFM using RNA sequencing: bluegill (Lepomis macrochirus) contain a niclosamide mixture. Bluegill were exposed to either TFM or niclosamide: niclosamide combination, alongside a period matched control gathering, and gill and liver tissues were inspected at 6, 12, and 24 h. We summed up the entire transcriptome designs through quality metaphysics (GO) term improvement and through differential articulation of detoxification qualities. The relatively high detoxification capacity of bluegill may be explained by an increase in the transcription of several transcripts associated with detoxification (cyp, ugt, sult, and gst) following the administration of niclosamide.