Jornal de Genômica Clínica e Médica

Does Resistin Gene Polymorphisms +299 (G>A) Participate in Insulin Resistance in Egyption Non-obese Type 2 Diabetes?

Abstract

Osama Khalil, Alsayed Alnahal, Mohamed Ghonium, Samy Fawzy, Magdy Ibrahem,Nermin Raafat and Walaa Samy

Background: Insulin Resistance (IR) is a condition which precedes the development of type 2 diabetes mellitus (T2DM). Resistin is a hormone secreted by adipocytes. Resistin gene (RETN) polymorphisms has been found to be associated with obesity and insulin resistance. We choose 60 patients have known type 2 diabetes mellitus against 45 healthy subjects to investigate the relationship between RETN +299 gene polymorphisms and insulin resistance, in non-obese patients with T2DM.

Results: The present study revealed statistically significant increase in AA and combined GA+AA genotypes (with ODD Ratio 4.04 and 4.75 respectively), and statistically significant decrease in GG genotype in non-obese T2DM as compared to the control subjects. Also we found statistically significant increase in A allele and serum resistin in T2DM group as compared to the control group. In addition there were statistically significant increase in mean value ± SD of fasting blood glucose, insulin, HOMA-IR, HbA1C%, Resistin, total cholesterol, triglyceride, LDL-C and statistically significant decrease in mean value ± SD in serum HDL-C in AA combined AA+GA subgroups as compared to GG subgroup of T2DM group.

Conclusions: Our study has shown that resistin +299G/A is an important genetic regulator that resulted hyperresistinemia and subsequently may be predisposing factor the development of T2DM in non-obese Egyptian population.