Revista de Ciências Químicas

Discovery of Highly Selective Kinase Inhibitors for the Treatment of Neurodegenerative Diseases

Abstract

Hamzat Adejoke

Neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's disease, represent a significant and growing global health challenge. These disorders, characterized by the progressive degeneration of nerve cells, lead to debilitating cognitive and motor impairments. As the global population ages, the prevalence of neurodegenerative diseases is on the rise, making it imperative to develop effective therapeutic strategies. Recent advances in the field of drug discovery have paved the way for the development of highly selective kinase inhibitors, offering new hope for the treatment of neurodegenerative diseases. Kinases are a class of enzymes that play a crucial role in cell signaling and regulation. They are responsible for phosphorylating proteins, thereby activating or deactivating various cellular processes. Aberrant kinase activity has been implicated in several neurodegenerative diseases. Dysregulated kinases can lead to the accumulation of toxic protein aggregates, neuroinflammation and oxidative stress, all of which contribute to the progression of these diseases.