Jornal de Histologia Molecular e Fisiologia Médica

Development, Cancer, and Aging: Insulin-Like Growth Factors

Abstract

Javed Khan

Insulin-like growth factors (IGFs) have piqued researcher’s interest in a variety of fields, including endocrinology, paediatrics, growth, metabolism, nutrition, ageing, and cancer, since their discovery in the late 1950s. IGF1, which was first discovered as a modulator of growth hormone activity, is now thought to be involved in a wide range of cellular and organismal activities. Over the last 40 years, the signalling pathways triggered by IGF1 have been thoroughly described in biochemical and molecular terms.