Jornal de relatos de casos clínicos

Cycloserine-Induced Fever in a Patient with Multidrug-Resistant Tuberculosis and its Successful Desensitization: A Case Report

Abstract

Shenglan Wang, Zhangli Peng, Jianyong Zhang, Ling Chen and Hong Zhang

Cycloserine is one of the second-line anti-tuberculosis drugs used for treating multidrug-resistant tuberculosis (MDR-TB). Psychiatric and neurologic adverse reactions of cycloserine are commonly observed; however, fever as its only adverse reaction was rare. Here we report a case of cycloserine-induced fever in a 23-year-old female patient with MDR-TB and its successful management. After desensitization, the patient was able to continue the treatment regimen for MDR-TB and her symptoms were improved significantly. Our case indicates that fever could be the only adverse reaction of cycloserine in a patient who uses cycloserine as part of a treatment regimen for MDR-TB and the fever is manageable.