Ciência e terapia do câncer

Clinical and Prognostic Significance of Promoter Polymorphism (-31GC)of Anti Apoptotic Gene Survivin (BIRC5) in North India Patients with Non Small Cell Lung Cancer

Abstract

Jamsheed Javid, AB Rashid Mir, Imtiyaz Ahamad, Shazia Farooq, Prasant Yadav, Maryam Zubari, M Masroor, PC Ray, PK Julka, Anant Mohan, Maqbool Lone, MA Banday and Alpana Saxena

Background: Apoptotic inhibitor gene survivin regulates apoptosis and cell cycle progression. Functional polymorphism in the promoter region of survivin influences its expression may lead to the development of several cancers including lung cancer. Our study aimed to investigate the association of survivin-31G>C polymorphism with the risk of NSCLC in Indian population.
 
Methods: A hospit al-based case control study of 136 cases and 136 age-gender matched healthy controls was performed by PCR-RFLP.
 
Results: Our findings reveal that a statistically increased risk and poor survival was associated with the BIRC5 -31CC genotype (OR 3.13, 95% CI 1.57- 6.25) compared to the genotype containing G allele GC (OR 1.22, 95% CI 0.69-2.14). In addition significant association was found with stage and distant metastasis status of NSCLC patients.
 
Conclusions: Our results conclude that the function polymorphism (-31G>C) in the promoter of survivin gene is associated with risk and susceptibility to NSCLC.