Amanda Carroll-Portillo and Henry C Lin
The gastrointestinal system offers a unique opportunity for observing the interactions between commensals of the microbiome and the host immune system that is functioning close to these micro-organisms. Bacteriophages are critical to maintenance of homeostasis in this environment, and influence immune responses both indirectly, through modulation of the bacterial population and directly, through specific interactions with the metazoan host. Understanding these interactions in health and in human diseases is critical for developing novel treatment. This focused review summarizes the current knowledge in this area.
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