Jornal de AIDS e Pesquisa Clínica

Anti-HIV Effects and Immune System Modulation of Fractionated Crude Extracts from Alternaria alternata

Abstract

Sizwe I. Ndlovu

HIV/AIDS remains a significant global health challenge, and there is a continuous search for novel antiviral agents. This study explores the anti-HIV activity and immunomodulatory effects of fractionated crude extracts of A. alternata, a filamentous fungus. The crude extracts were fractionated into various components, which were then tested for their potential to inhibit HIV replication and modulate immune responses. The results demonstrated that certain fractions of A. alternata exhibited substantial anti-HIV activity by reducing viral replication and enhancing the host immune response. These findings suggest that A. alternata could be a valuable source of new therapeutic agents for HIV treatment and warrant further investigation into its active compounds and mechanisms of action.