Ciência e terapia do câncer

Anticancer Strategy Targeting Mitochondrial Biogenesis in Ovarian Cancer

Abstract

Md. Hafiz Uddin, Boyun Kim, Dong Hoon Suh and Yong Sang Song

Mitochondrial biogenesis (MtBIO) is the utmost requisite for cell’s replication and survival, and it has been found to be involved in chemoresistance. The chemoresistance is the foremost obstacle in the treatment of patients with ovarian cancer. Several studies showed that modulation of MtBIO can lead to cancer cell death. Therefore targeting MtBIO in ovarian cancer could be a promising therapeutic approach possibly through overcoming the chemoresistance. Potential targets of MtBIO will be discussed focusing on ovarian cancer in this review.