Jornal de relatos de casos clínicos

Acute Myocardial Infarction Following 5-Fluorouracil Treatment

Abstract

Jose Rivas Rios, Melissa Oye, Yixin Zhang, Fabiana Rollini and Kadeja Esmail

A 62-year-old male with recently diagnosed stage IV pancreatic cancer was started on chenotherapy with 5-Fluourouracil. Shortly after initiation, he suffered cardiac arrest. We will review the proposed pathophysiology of 5-Fluourouracil cardiotoxicity, the reported incidence, treatment, and the antidote for 5-Fluorouracil overdose or toxicity. Myocardial infarction is an adverse cardiac reaction associated with 5-fluorouracil (5-FU). Data on the incidence, risk, and prognosis of 5-FU-related myocardial infarction are limited. Fluorouracil (5-FU) is the most commonly proposed chemotherapy drug for colorectal cancer. Cardiogenic side effects such as autopsy arterial vessels seizures, ventricular arrhythmias, and cardiac ischemia are also rare.