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A Comparative Study of the Combination of Drugs - Amoxicillin with Metronidazole and Ofloxacin with Ornidazole In the Treatment of Dentoalveolar Abscess

Abstract

Prathiba S* and Mahesh Kumar P

To compare the efficacy of combination of capsule. amoxicillin 500 mg with tablet. metronidazole 400 mg at 8 hrly interval with fixed dose combination of tablet. Ofloxacin (200 mg) + ornidazole (500 mg) at 12 hrly interval for 5 days in the treatment of dentoalveolar abscess. Materials and method: This comparative study included sample size of 160 patients recorded within 6 months and diagnosed clinically with dentoalveolar abscess visiting dental unit of Saveetha Medical college: in order to match the estimated sample size a few patients from Mohit private dental clinic, Valasaravakam were included. A standardized method for data collection and oral examination was followed. The patients were recruited to anyone of the two groups to which the investigator was blind. The treatment allotment code was kept confidentially with the treating dentist and only at the end of the study the code was broken and revealed to the investigator. The patients were advised to come for check up on the third day. In case if any problem arised before the advised visit, due to the condition or the therapy, the patients were informed to contact the treating dentist. Assessment of clinical improvement in swelling size, mouth opening, pain, lymph node condition and body temperature were carried out during the assessment visits on the third day and the fifth day. If clinical improvement was present- the patient was advised anyone of the following treatments that suited his/her clinical condition. The tooth was treated either by root canal treatment or extraction. The subject’s whose clinical condition was not improved on the third day was advised to take the prescribed medicine for two more days and to come for dental checkup on the fifth day. Results: The efficacy of both therapies was similar. No significant difference in adverse drug reaction. Patient compliance was in favour of ofloxacin and ornidazole group. Cost of fixed dose combination of ofloxacin and ornidazole therapy was slightly cheaper than amoxicillin and metronidazole. Conclusion: We conclude that the efficacy of both the therapies was similar with no significant difference in adverse drug reaction. The patient compliance was in favor of oflaxacin and ornidazole group of drugs which was relatively cheaper than amoxicillin and metronidazole.